Effects of perfluorooctane sulfonate on serum thiiodothronine, thyroxine and thyroid-stimulating in rats

ZHANG Yinghua; FAN Yiou; MA Yixin

doi:10.11847/zgggws2005-21-06-44

ZHANG Yinghua, FAN Yiou, MA Yixin, . Effects of perfluorooctane sulfonate on serum thiiodothronine, thyroxine and thyroid-stimulating in rats[J]. Chinese Journal of Public Health, 2005, 21(6): 707-707. DOI: 10.11847/zgggws2005-21-06-44

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Effects of perfluorooctane sulfonate on serum thiiodothronine, thyroxine and thyroid-stimulating in rats

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Abstract

Objective To explore the effects of perfluorooctane sulfonate(PFOS)on the thyroids of rats.
Methods Rats were fed forage with 0.5, 1.5, 4.5 mg/kg PFOS.After 65 days, serum thiiodothronine(T3), thyroxine(T4)and thyroid-stimulating(TSH)were analyzed by enzyme exaggeration radioimmunoassays.
Results Serum T3 and T4 in the PFOS -treated rats were significantly reudced compared with the corresponding animals in control group, but didn't show any dose -effect relationship.There was no substantial idfference of TSH.
Conclusion PFOS could reduce serum T3 and T4.

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Effects of perfluorooctane sulfonate on serum thiiodothronine, thyroxine and thyroid-stimulating in rats

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