Effect of Ribavirin on anti-adenoviruses 3 type in vitro

  Objective   To study the inhibition action of the Ribavir in to Adenoviruses 3(ADV3).

  Methods   The anti ADV3 effect of the ribar irin in Hela cell culture was observed by means of the inhibition of cytopathic effect.

  Results   In cell culture, the Ribavir in was found to be a inhibitor of ADV3 in a concentration dependent manner toxic concentration(TC50)of the Ribavirin was 2056.13 g/ml, the median effective concentration(EC₅₀)of the Ribavirin to ADV3 was 53.03 g/ml, the selectivity index(TI)was 38.77.The Ribavirin could effectually inhibit replication of ADV3 when it was added in Hela cell within 10 hours after virus infection.

  Conclusion   The Ribavirin has the evident inhibition actions to ADV3.