Effect of new pesticide on DNA damage in different mice cells

  Objective   To study the effects of a new pesticide on DNA damage of erythroblast cells and seminal cells in mice in vitro.

  Methods   The comet assay was used to detect the DNA damage induced by a new pesticide compound at the different dose.

  Results   Compared with the control group, the DNA migration rate were increase sig nificantly at(10 g/L)test doses to erythroblast cells(P < 0.05).D NA migration of seminal cells(at test dose of 10, 100, 500 mg/L)exhibited significant dose-effect relationship.The DNA damage in seminal cell was more sensitive than that of erythroblast cell.

  Conclusion   The new pesticide could cause DNA damage of mice cells in vitro.