Effects of resveratrol on genital system in ovariectomized rats

  Objective   To investigate the estrogen like effects of resveratrol on ovar iectomized rats.

  Methods   Forty eight Sprague Dawlery female rats were randomly divided into 6 groups and treated respectively as follows: group A, shamoperated; group B, ovariectomized(OVX); group C, OVX supplemented with 0.03 mg/kgbw·d diethylstilbestrol; and group D, E, F: OVX rats supplemented with 3 dosages of RES(5, 15 and 45 mg/(kg·bw).The duration of exposure was 90 days and the estradiol serum concentration, vaginal smear, uterus index and pathologic examination on uterus of rats were observed.

  Results   Serumestr adiol concentration of group A was higher than that of the other 5 groups significantly(P < 0.05).Vaginal smear examination showed that resveratrol could induce the estrus occurrencing in the OVX rats.Uterus index of group A was higher than that of the group D, E and F significantly(P < 0.05), but lower than that of group C significantly at the same time.

  Conclusion   Resveratrol had mild estrogen effect on ovariectomized female rats and without endometrial hy perplasia adverse effect.