Effect of organic pollutants from J river on hepatic and renal toxicity of rats

  Objective   To investigate the hepatic and renal toxicity of organic pollutants from J River in rats.

  Methods   Organic extract was collected with method of solid phase extraction.At 4, 24, 144 L/(kg·bw)doses of pouring into stomach, patholo gical changes, hepatic and renal function and lipid perox idation were studied in subacute tox icity test(14 d).

  Results   In the 144 L/kg dose group, vacuolar degeneration was found both in liver and kidneys.Values of aspartate transaminase (AST), uric acid(UA)and trigly ceride(TG)in serum increased greatly.High levels of total superoxide dismutase(T-SOD)activ ity and malondialdehyde(MDA)were detected in the two or gans.

  Conclusion   In the higherex perimental dose, organic extract from J River has potential toxicity of the liver and kidney, and lipid peroxidation may be one of the mechanisms of the impairing.