Protective effect of soy isoflavones combined with calcium and bone collagen on bone quality in postmenopausal osteoporosis

  Objective   To observe the effect of soyisoflavones combined with calcium and bone collagen on bone mineral density(BMD)and biomecthanics in ovariectomized(OVX)rats.

  Methods   Female rats except sham group were ovar iectiomized.All rats were administered with different diets for 12 weeks.BMD and indexes of biomechanics were detected in grouped rats including OVX, sham, low dose combination, middle dose combination, high dose combination and calcium carbonate groups.

  Results   The combination could significantly increase the BMD and some indexes of biomechanical in the ovariectomized rats.

  Conclusion   The combination can increase the BMD and improve bone biomechanics and benefit postmenopausal osteoporosis(PMOP).