Relationship between ALDH2 genetic polymorphisms and environmental exposure and susceptibility to gastric cancer

  Objective   To evaluate the association between(ALDH2)genetic polymorphisms and some risk factors and susceptibility to gastric cancer in Nanjing population.

  Methods   PCR-Amplified product length polymorphism(PCR-APLP) technique were used to analyze the genetic polymorphisms of ALDH-among 169 cases of gastric cancer and a control group of cancer-free and matched by age(±5 years)and sex.Each subject was asked to answer a questionnaire about epidemiology of gastric cancer and was phlebotomized to test association between the interaction of ALDH-genetic polymorphisms and some risk factors and susceptibility to gastric cancer.

  Results   There was significant difference of the frequency of ALDH-genotypes between case group and control group(χ ²=4.617, P=0.032).Cigarette smoking, bloat food, having meals indefintely, engorgement was significantily associated with gastric cancer susceptibility.

  Conclusion   The genetic polymorphisms of ALDH-might contribute to gastric cancer susceptibility and interact with environmental exposure.