Analysis on dynamic changes of urine N-aceyl-β-D-aminoglycoside enzyme activities in patients with chronic phosphorus poisoning

  Objective   To investigate the dynamic changes of urine N-aceyl-B-D-aminoglycoside enzyme(NAG)activityes in patients with chronic phosphorus poisoning and to understand the value of the changes.

  Methods   Urine NAG activities were detected by nitrox ylphenol in both patient group and control group and data were analyzed between two groups.

  Results   No significant difference on urine NAG activities(P > 0.05)was found between patient group and control group in the first year after phosphorus poisoning, while in the second to fifth year respectively, the urine NAG activities were all significantly higher in the patient group than those in the control group(P < 0.01).

  Conclusion   Urine NAG activity plays an important role in judging the kidney damage of patients with chronic phosphorus poisoning and is a sensitive factor in diagnositics of chronic phosphorus poisoning.