Effect of dibutyltin dilaurate on hepatic toxicity in rats

  Objective   To study the effects of dibutyltin dilaurate(DBTD)on hepatic system and the activity of enzyme in serum of rats.

  Methods   28 health rats were chosen to do the experiment, and 7 animals in each group.The rats were administrated orally with DBTD at the dose of 0, 5, 10 and 20 mg/kg respectively, and killed 5 weeks later.Alkaline phosphatases (AKP), glutamic-pyruvic transaminase enzyme(GPT)and gamma glutamy ltransferase(GGT)in serum, and acid phosphatases (ACP), alkaline phosphatases(AKP), lactate dehydrogenase enzyme(LDH), tin content in hepatic tissue were measured.

  Results   The DBTD content of hepatic tissue was higher than that in control group(P < 0.05), and the activities of ACP, AKP and LDH in hepatic tissue were higher than those in control group(P < 0.05), at the same time the activities of ALP, GGT and GPT were also obviously higher than those in control group(P < 0.01).

  Conclusion   DBTD can accumulate in hepatic tissue and has hepatic toxicity, so it can affect the activity of enzymes in liver and the liver's normal function.