Antiradiation effect of wild lactarius volemus on mice

  Objective   To observe the antiradiation effect of wild lactarius volemus on ince in Guizhou province.

  Methods   Mice were randomly divided into 5 groups: 3 test groups administered with lactarius volemus2.3, 4.5, 9.0 g/(kg·bw)respectively, negative control group, and positive control group.Mice were dealt with 5 Gy irradiation in test and positive groups.The numbers of peripheral blood leukocytes, the contents of bone marrow DNA, and the poly chromatic erythrocytic (PE)micronucleus formation rate of bone marrow were detected.

  Results   The numbers of peripheral blood leukocytes in test groups were sig nificantly more than that in positive control group on day 5 after irradiation(P > 0.01);there were negative correlation between the dose of lactarius volemus and the level of DNA damage and had dose-effect relationship on days 4, 15 after irradiation(P < 0.05).Micronucleus rate in the high dose group9.0 g/(kg·bw)were significantly lower than that in the positive control on days 4 after irradiation(P < 0.01).

  Conclusion   The wild lactarius volemus protects the mice from the damage of leukocytes and DNAinduced by irradiation.In the 9.0 g/(kg·bw)group, wild lactarius volemus is of a better protection against the damage of chro mosome induced by irradiation.