Establishment of rat model of DDP-induced renal anemia

  Objective   To establish the rat model of cis-diamine-dichloro-platinum(DDP)-induced renal anemia.

  Methods   The rats were intravenously injected with DDP(8mg/kg), and serum EPO levels were measured by 3H-TDR incorporation in fetal mouse hepato cytes.Moreover, the changes of renal tissue were studied by light microscope and electron microscope.

  Results   The number of red blood cell, hemoglobin concentration, reticulocytes and serumer ythropoietin(EPO) were greatly decreased, serum urea nitrogen elevated significantly, pathological findings revealed that DDP might significantly cause renal damage in rats.

  Conclusion   Rat model of renal anemia could be induced by DDP.