Relationship between polymorphisms of DNA repair genes and esophageal cancer susceptibility

  Objective   To explore the relationship between the polymorphisms of XPA(A23G), XPD(Lys751 Gln), XRCC1(Argl94 Trp and Arg399Cln)and XRCC3(Thr/Met)genotypes and susceptibility to esophageal cancer in Huaian Han population, China.

  Methods   A 1:1 case-control study was conducted among 106 ESCC patients and 106 control subjects (matched by age±5 years and gender).PCR2RFL P method was used to detect genotypes.

  Results   There was significant difference of distribution of mutanthomozgote of XPA 23 and XRCC1 399 genotype between cases and controls(χ²=4.027 7, P=0.044 8;χ²=4.745, P=0.029, respectively).Individuals with mutant allele of XPD751, XRCCI194 or XRCC3241 genotype did not show the rising risk of esophageal cancer(OR=1.424, 95%CI=0.621~3.263;OR=0.826, 95%CI= 0.857~1.381;OR=1.276, 95%CI=0.483~3.371, respectively).

  Conclusion   The polymorphisms of XPAA23G and XRCC1 Arg399 Gln were related to the susceptibility of esophageal cancer in Huaian Han population.