Relationship between N-acetyltransferases genetic polymorphisms and susceptibility to stomach cancer

  Objective   To determine the association of N-acetyltransferases 2(NAT2)genetic polymorphisms and the susceptibility to stomach cancer.

  Methods   1:1 case-control study and PCR technique were used to analysis the genetic polymorphisms of NAT2 genoty pe among 121 cases of stomach cancer patients and sex-and age-matched controls, who were selected in Nanjing.Statistical analysis was performed to elucidate the risk for stomach cancer.

  Results   NAT2M1 mutation genotype was significantly associated with the increase of the risk of stomach cancer(OR=11.079, 95%CI=4.421~27.765), while NAT2M2, NAT2M3 mutation and geno type were not statistically significant.

  Conclusion   NAT2M1 mutation genotype was likely associated with the susceptibility to stomach cancer.