Association of MICA gene polymorphism and gastric cancer risk

  Objective   To investigate the possible association of MICAgene polymorphism, especially allele and phenotype of allele 5.1(A5.1), with the risk of gastric cancerand evaluate the possible association of HPpositive ornegative with the gene polymorphism.

  Methods   MICApolymorphism was analyzed in 100 gastric cancerpatients and 220 were randomly selected unrelated controls in Jiangsu province, China by usinglocus-specific prime polymerase chain reactions(PCR), followed by electrophoresis of the PCRproducts in denaturing polyacrylamide gels and subsequent detection by silverstaining.HPwas detected by ureCPCR.

  Results   The phenotype frequency of allele A5.1 of MICAin subjects with gastric cancerwas significantly higherthan thatin controls, as was the frequency of allele.Simultaneously, the phenotype frequency of allele A5 of MICAin subjects with gastric cancerwas significantly lowerthan thatin controls, as was the frequency of allele.

  Conclusion   Allele A5.1 in MICAmight conferthe risk of gastric cancer, and allele A5 seems to be one of protective factors against development of gastric cancer.