Anti-fibrosis effects of vitamins on rats with immune hepatic fibrosis

  Objective   To research and to compare the effects of several vitamin on rats with hepatic fibrosis.

  Methods   The rats with immune hepatic fibrosis were treated by VA, β-CAR, VC and VE.The anti-fibrosis effects were evaluated and compared with histopathology of liver tissue, four fibrosis serum marker and the expression of TGFβ₁ mRNA and TIMR-1 mRNA in liver tissue.

  Results   The semiquantitative scoring system(SSS)of liver tissue were 8.00±4.14, 6.25±4.47, 13.13±7.54 and 5.06±3.06 in VAβ, -CAR, VC and VE group respectively.The SSS was significantly lower in VA β, -CAR and VE group compared with model group, but no significantly difference between VC and model group was found.The general scoring of four fibrosis serum markers in VAβ, -CAR and VE group was lower than that in model group.The general scoring in VE group was also lower than that in VA and VC group but no significantly difference berween VE and β-carotene group.The expression of T GFβ₁ mRNA in liver tissue was markekly β-carotene group.The expression of TGFβ₁ mRMA in liver tissue was markedly inhibited by VAβ, -CAR and VE and the expression of TIMP-1 mRNA in liver tissue was also inhibited by VE.

  Conclusion   VAβ, -CAR and VE all have anti-fibrosis effects on rats and VE is more excellent than VA on anti-fibrosis effects but no difference compared withβ-CAR.No effects are found in VC group.