Association of vitamin D receptor polymorphism with susceptibility to esohageal cancer

  Objective   To explore the association between vitamin D receptor(VDR)polymorphism and the susceptibility to esophageal cancer.

  Methods   Polymerase chain reaction-restriction fragent length polymorphism(PCR2RFLP)method was used.A restriction fragment length polymorphism in the 3'region of VDR gene, TaqⅠ, was tested in 92 patients with esophageal cancer and 115 healthy controls.

  Results   Allele frequencies of TaqⅠpolymorphism had significant differences between the two groups.Compared with people with TT genotype, those with Tt and tt genotypes had less risk to esophageal cancer.

  Conclusion   There is an association between VDR plymorphism and the susceptibility to esophageal cancer, and Tt and tt genotypes decline the susceptibility to esophageal cancer.