Study on characteristics of arsenic metabolism and DNA damage between mother and child under arsenic exposure

  Objective   To explore the characteristics of arsenic metabolism and DNA damage of children under arsenic exposure through the detection of arsenicals and 8-OHdG in urine, and to explore whether there is a difference of arsenic exposed effects between children and adults.

  Methods   Arsenicals were measured by the hydride generation-cold iron captureatomic absorption spectrophotometry; 8-OHdG levels were detected by detection kit.

  Results   The level of inorganic arsenic (iAs), monomethylarsonate acid(MMA), dimethylarsinic acid(DMA)and total arsenic(tAs)of female and children of the exposed group were significantly higher than those of control's.Between the arsenic exposed mother and child, the level of iAs, DMA, tAs and DMA/tAs of the child were markedly higher than those of their mother's, while MMA/(MMA+DMA)was significantly lower than that of their mother.There was no significant difference of 8-OHdG level between mother and child.

  Conclusion   The secondary arsenic methylation of children under arsenic exposure is stronger than that of adults.There is no significant difference of DNA damage between arsenic exposed children and adults.