Analysis on genotype of mumps virus strain circulating in Beijing city

  Objective   To understand geographic distribution of mumps virus genotypes and variation of circulating mumps virus strains in Beijing.

  Methods   SH genes were analyzed.Genetic homology between the Beijing strains and other reference mumps strains were analyzed.

  Results   17 strains were all genotype F, and VAC-S79 was genotype A.The circulating viruses showed 5.4% sequence divergence, and 4.8% sequence divergence from Z77.58(Lanzhou); 7.0% from Z77.60 (Shanghai); 14.6%~15.9% from VAC-s79.

  Conclusion   Genotype F is the main genotype of circulating strains in Beijing.Although all the circulating strains have genotype F, there are some variations between them.As the rate of variation is tend to increase, it seems necessary to follow up the molecular epidemiology.