Effects of mixed pesticides on somatosensory evoked potential and activities of ATPase of brains in rabbits

  Objective   To explore the effects of mixed pesticides on the Somatosensory evoked potential(SEP)and the activities of ATPase of brains in rabbits.

  Methods   Rabbits were divided into 2 mixed pesticide ex posure groups and 1 control group.A group were poisoned by profenofos and fenvalerate, and B group were poisoned by profenofos and methomyl.The SEP were measured in each group before and after poisoning by mixed pesticide, and the activites of Na⁺-K⁺-AT Pase and Ca²⁺-Mg²⁺-ATPase of the brain was measured in each group after poisoning by mixed pesticide.

  Results   Compared with the control group, the potential periods of N1, P2, N2 in high-dose exposure group in Agroup and Bgroup delayed significantly after poisoning by mixed pesticide(P < 0.01).Compared with the control group, the activities of Na⁺-K⁺-ATPase and Ca²⁺-Mg²⁺-ATPase decr eased significantly in high-dose exposure groups and middle-dose groups in A group and B group after poisonging by mixed pesticide(P < 0.05, P < 0.01).

  Conclusion   The mixed pesticides can harm the functions of central nervous system, which must be related to the decrease of the activities of Na⁺ K⁺-ATPase and Ca²⁺-Mg²⁺-ATPase in brain.