Primary study about reproductive toxicology of DHPO in mice

  Objective   To evaluate the acute toxicity and reproductive toxicology of deferiprone(DHPO)under various doses and during different periods.

  Methods   Median lethal dose(LD₅₀)test was per for med, then Kun Ming mice were administrated different doses of DHPO to cary out the sperm malformation test under low(1/8 LD₅₀), mid(1/4 LD₅₀), high(1/2 LD₅₀)doses.

  Results   LD₅₀ of DHPO was 562.34 mg/kg by gavage on mice.There were no significant differences in 1/8 LD₅₀ group and 1/4 LD₅₀ group in compar ison with negative control group in obser vations conducted din the 14^th, 28^th, 35^th, 42^nd, and 70^th day(P > 0.05);While significant differences appeared between 1/2 LD₅₀ group and in negative control group in observations conducted in the 14^th, 28^th and 35^th day(P < 0.05);There were no significant differences between 1/2 L D50 group and negative control group in observations conducted in the 42^nd day and 70^th day(P > 0.05).

  Conclusion   There is no evidence to indicate that 1/8 LD₅₀, 1/4 LD₅₀ dose have reproductive toxicology(P > 0.05).High dose of DHPO(1/2 LD₅₀) has some degrees of reproductive toxicology, but can recover within 42 days.