Effect of chronic lead exposure on protein expression of CaMKII in mice

  Objective   To observe the effect of chroniclead contaminant on protein expression of Ca²⁺/calmodulin dependent protein kinase II(CaMK II)in hippocampus of mice.

  Methods   Chronic acetic lead contaminant was applied on mice(2.4, 4.8, 9.6 mmol/L), and pups were killed at 14, 28, 42, 56 d respectively.Western blotting was used to observe protein expression of CaMKII in hippocampus of mice.

  Results   Compared with control group, CaMKII protein expression of chronic lead exposure mice in the hippocampus was downtrend.2.4 mmol/L lead exposure could make the protein expression at 14 days higher than that of control(P > 0.01), but at follow days lower than that of control.As to 4.8 mmol/L and 9.6 mmol/L concentration, the protein expression was always lower than that of control(P < 0.05).

  Conclusion   Chronic lead exposure can disturb the normal change of CaMKII protein expression in mice.