Effect of L-Arg on lipid peroxidation and cellular membrane lipid fluidity subjected under heat stresses in mice

  Objective   To explore the effect of L-Arg on mice lipid peroxidation and cellular membr ane lipid fluidity subjected under high temperature.

  Methods   Male adult SD mice were randomly divided into three groups, fed 12 days, exposed under heat str esses, sampled at differenthours through heat stress.The activity of superox ide dismutase(SOD)in serum and the yield of malondialdehy de(MDA)were measured with kit.Using Laser Scanning Confocal Microscopy(LSCM)and linearity quantitation scanning to detect the cellular membrane lipid fluidity.

  Results   After heat stress SOD of all groups were higher than control group, group B and group C were obviously higher than group A((P < 0.05).The yield of MDA had stepped up than before, By the time adding, MDA of group B and group C were lower than group A(P < 0.05).Cellularmembr ane lipid fluidity group B and group C after heat str ess were higher than before, and it were also higher than group A under heat stress(P < 0.05).

  Conclusion   Appropriate L-Arg suplement could increase the activity of SOD in serum, decrease the yield of MDA, keep the cellular membrane lipid fluidity efficiently, in order to inhibit injury of lipid peroxidation.L-Arg has the same antiox idation as VE, It is presumed that possibly throught increasing the activity of SOD and by L-Arg-NO pathway.