Effect of buckthorn abstract on myocardium pathological changes in breast cancer patinets with chemotherapy

  Objective   To study the effect of buckt horn abstract on the breast cancer pat ients who need chemotherapy with CEF in order to reduce the cardiac toxicity.

  Methods   All the 60 patients were divided into experimental group and controlled group(n=30).All the patients were chemot herapied with CEF scheme rgularly.Experimental group took buckthorn abstract a week before chemotherapy(300 mg/d), controlled group took placebo with the same dose at the same time.The changes were obser ved in electrocardio gram(ECG), LVEF and myocadial enzyme.

  Results   When epirubicin cumulative reached to 480 mg/m², the rate of arrhythmia and ST-T change in experimental group were 6.7% and 13.3%, which were differed from controlled group(P < 0.05), LEVF in experimental group differed from controlled group(P < 0.05).Myocadial enzyme of experimental group(3.3%)differed from controlled group(13.3%)significantly(P < 0.01).

  Conclusion   Buckthorn abstract has well effect on reducing the cardiac toxicity of the breast cancer patients with chemtherapy.