Effects of BaP on apoptosis of liver cells in mice

  Objective   To study the effects of BaP on apoptosis through the Fas/Fas-Lsignal pathway in mice liver cells.

  Methods   ICR mice were divided into five groups, control group and BaP treated group, which were oral exposure withoil and BaP(5, 10, 20, 40 mg/kg)respectively.Immunohistochemical method was utilized to detect the expressions of Fas, Fas-L, caspase-3 and the apoptosis were measured by AO/EB double stained method.

  Results   The expressions of Fas, Fas-L, caspase-3 and apoptosis rate in BaP treated group were significantly higher than those in control group(P < 0.05).

  Conclusion   BaP could induce apoptosis in mice liver cells and the Fas/Fas-Lsignal pathway was one of the important pathways.