Objective To evaluate the transformation of the hepatitis B virus sur face antigen(HBsAg)car riers.
Methods Aretrospective questionnaire investigation with serological examine was used in this study to evaluate the transformation of HBsAg carriers.The transformation outcome included the chronical Hepatit is B, liver cirrhosis, liver cancer and death.
Results 197 HBsAg carriers(meanage of 46.19?9.48 years)were followed up by retrospective study.The follow-up time was over 8 years(from 8 to 34 years).The cumulative cases of negative HBsAg, chronical Hepatitis B, liver cirrhosis and liver cancer were 2, 33, 9 and 10, respectively.The cumulative cases of death were 11, meanw hile 9 died of liver cancer and 2 died of liver cirrhosis.The proportion of chronical Hepatitis B, liver cirhosis and liver cancer in the male(39/103)were more than the proportion in the female(19/94)greatly(χ2=14.61, P < 0.05).
Conclusion The probability that the positive HBsAg turned into negative is small.The HBsAg carriers should have body examined frequently.
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