Effects of monobutyltin or dibutyltin on DNA damage of mice bone marrow cells

ObjectiveTo study the effects of monobutyltin or dibutylt in on DNAdamage of mice bone marrow cells in vitro.MethodsThe DNA damage was observed by means of comet assay.ResultsCompared with the control group,the treated groups of 1×10^-10、1×10^-11 g/L monobutyltin or dibutyltin were significantly different(P<0.05,P<0.01).The DNA damage increased with the increase of dose and there was significant dose-effect relationship.Significant difference was found among the treated groups.ConclusionMonobutylt in or dibutyltin could cause DNA damage of mice bone marrow cells in vitro.