Analysis on plasma tissue factor and related factors in patient with coronary heart disease

ObjectiveTo study the relatio nship between plasma tissue factor and coronary heart disease.Methods237 patients suspected of coronary heart disease(CHD)were divided into two groups according to the result of coronary angiography:CHD group(n=149)and control group(n=88).The total cholesterol,triglycerides,low density lipoprotein cholesterol, high density lipoprotein cholesterol,blood sugar,serumuric acid,high sensitivity C-reactive protein,fibrinogen and plasma tissue factor were determined in all the patients.After the influence of other risk factors were controlled,the relationship between plasma tissue factor with CHD and other risk factors of CHDwas analyzed by linear correlation and multiple stepwise reg ression.ResultsThe level of plasma tissue factor in CHDgroup was significantly higher than that of control group(P<0.01).The difference of plasma tissue factor between man and women subgroup was not significantly in both CHD group and control group(P>0.05),but in that diabetes and non-diabetes subgroup,the difference was significantly(P<0.05).There was a positve correlation between plasma tissue factor with the occurrence of CHD(r=0.791,P<0.001).And plasma tissue factor correlated with diabetes,LDL-C、Lp(a)Hs-CRP、FIB(respectively r was 0.172,0.180,0.147,0.380,0.175.all P<0.05).Excluding the influence of age,LDL-C,blood pressure,blood glucose,smoking,etc,multivariate stepwise regression analysis showed that TF was a significant variable associated with the occurrence of CHD.ConclusionHigh tissue factor level may be one of the important risk factors for CHD.Elevated tissue factor can induce thrombog enesis,enhance the onset and development of CHD.It is also a prognostic factor for patients with CHD.