Body mass index,waist to hip ratio and the risk of benign prostatic hyperplasia in elderly

Objective To explore the association between body mass index(BMI),waist to hip ratio(WHR)and clinical benign prostatic hyperplasia(BPH)risk in older men.Methods A hospital-based case-control study was conducted.Cases(n=280)were men surgically and histologically confirmed with BPH,and controls(n=280)were men admitted to hospital for different diseases not related with prostatic conditions.Using a structured questionnaire,all subjects were interviewed and waist and hip circumference of the subjects were measured.The odds ratios(OR)and 95% confidence intervals(CI)of BPH for BM I and WHR were estimated with unconditional multiple logistic regression models.Results WHR≥0.9 was positively related to BPH(compared with WHR<0.9:O R=1.16,95% CI 1.05～4.87,P<0.05).Age-adjusted relative risks for BPH in WHR≥0.9 versus WHR<0.9 stratified by BM I(obesity)were estimated.For men who were overweight(BM I 24.0～27.9)or obesity(BM I≥28.0),WHR≥0.9 was associated with a significantly increased risk for clinical BPH(compared with WHR<0.9:OR=2.65,95% CI 1.33～6.96 and O R=3.00,95% CI=1.81～8.84,respectively).Conclusion Obesity(especially central obesity)is an important risk factor of clinical BPH.For overweight or obesity,central obesity is associated with a significantly increased risk of clinical BPH.