Association between PLA2 gene polymorphism and schizophrenia

Objective To investigate the genetic association between PLA2 G4C gene polymorphism and schizophrenia in the north Han Chinese.Methods The method of PCR-based ligase detection reaction(PCR-LDR)was applied to genotype 3 single nucleotide polymorphisms(SN Ps)of PLA2 G4C gene among 201 pedigrees consisting of father,mother and affected offsprings with schizophrenia.Haplotype relative risk test(HRR),transmission disequilibrium test(TD T)and clinical symptom analysis were conducted to analyze the genotyping data.Results The genotypic frequency of PLA2 G4C gene did not deviate from Hardy-Weinberg equilibrium in both case and control groups.HRR and TD T showed that the 3 SN Ps were not associated with schizophrenia(P>0.05).Analysis for clinical symptoms association showed that Rs2307279 was associated with delusion of sin(χ²=5.755,P=0.016).rs2.62886 and rs89.014 were associated with illogic of thinking and the character before illness(χ²=6.777,P=0.009;χ²=11.113,P=0.001;χ²=12.468,P=0.002;χ²=9.924,P=0.007).Rs2.62886 was associated with monstrous behavior(χ²=5.409,P=0.020).Conclusion PLA2 G4C gene polymorphism is associated with clinical positive symptoms of schizophrenia.