Epidemiological trend of hepatitis B, liver cirrhosis and liver cancer during 1990-2007 in Shandong province, China

ObjectiveTo analyze the epidemio logical trend of hepatitis B,liver cirrhosis and liver cancer during 1990 to 2007 in Shandong province,and to evaluate the effectiveness of hepatitis B prevention and control measures,so as to provide the evidence for policy-making.MethodsBased on the routine incidence data of hepatitis B,mortality data of hepatitis B,liver cirrhosis,liver cancer and demographic data,the incidence rate,mortality rate and age-specific mortality rate were calculated and analyzed with simple linear regression model.ResultsA total of 437094 cases of hepatitis B were reported during 1990-2007 with an average yearly morbidity of 27.32 per 100 000 population and a decreased trend for the 0-9 year-old children.At the same time,the adjusted mortality rate for hepatitis Band liver cirrhosis showed a decreased tendency signifcantly and the combined mortality rate decreased from 17.55/100 000 in 1990 to 4.01/100 000 in 2007.While there was a steady tendency for liver cancer(P=0.999 8).ConclusionThe good immunization work of hepatitis B vaccine can lower the incidence of hepatitis B for the target population and the mortality rates of related liver cirrhosis and liver cancer.