Study on genetic association between the polymorphism of KPNB1, KPNB2 and schizophrenia

ObjectiveTo investigate the association between schizophrenia and thepolymorphism of karyopherin beta1 (KPNB 1) and karyopherin beta-2(KPNB 2).MethodsPCR-restriction fragment length polymorphism (RFLP) was used to examine two single nucleotide polymorphisms(SNPs) of rs11871606 at the KPNB1 locus and rs266443 at the KPNB 2 with 233 nuclear family trios of schizophrenia.The Hardy-Weinberg equilibrium for genotyp is distribution was estimated by the goodness-of-fit test.The UNPHASED program was applied to perfoun the transmission disequilibrium test (TDT) and the combined effect analysis of the paired SNPs.ResultsThe genotype frequency distributions of hvo SNPs were in accordance with the Hardy-Weinberg equilibrium.The results of TDT indicated that the allelic frequency tmnsm fitted from the heterozygote parents did not deviate from 50%.The results of the combined effect analysis showed that rs11871606-rs266443 was not associated with schizophrenia.ConclusionAs far as Chinese Han schizophrenia concerned in this paper, we may not be assured the association between the polymorphism of KPNB 1 or KPNB 2 and schizophrenia.