Oxidative damage of perfluorooctane sulfonate on lipofuscin levels in rat livers

ObjectiveTo evaluate oxidative damage of perfluorooctane sulfonate(PFOS)subchronic exposure on lipofuscin (LF) levels in rat livers.MethodsTwenty-fourmale SD rats were randomly divided into 4 groups The rats were administrated with PFOS at concentrations of 1.7, 5.0, 15.0mg/L, in drinking water, respectively.After 90 days of exposure,liver somatic index, seiwn PFOS concentration, levels of maglonydiadehyde (MDA),LF and total antioxidant capacity(T-AOC) in liver were deteunfined.ResultsAfter 90 days exposure, body weights of rats in dosage groups showed no significant difference with those in control group(P>0.05).In 5.0, 15.0mg/L, PFOS dosage groups, liver weight and liver somatic index, serum PFOS concentration, levels of MDA and T-AOC in liver increased(P<0.05).In 15.0 mg/L PFOS dosage group, levels of LF were significantly higher than that of the control group.ConclusionIt is suggested that PFOS could induce the oxidative damage and increase the levels of LF in rat livers.