Effects of multinutrients supplementation on body weight and serum lipids in rats

Objective To explore the effects of multinutrient on body weight and serum lipids in diet-induced obese and hyperlipemia rats.Methods Multinutrients were administered to high calorie diet-induced obese and hyperlipidemia rats,which were randomly divided into three dose groups and a base model group.The obesity status were determined,the levels of serum lipids were assessed by enzymatic method.Results Compared with the obese group,there were significant decreases in body-weight,fatmass and food utilization ratio in multinutr-ients-treated groups(P<0.05).The rats in the three multinutrients dose group did not show significant difference in food intake(P>0.05).Compared with hyperlip idemia group,the levels of triglyceride,total cholesterol and low density lipoprote in cholesterol were significantly decreased in the multinutrients-treated groups(P<0.05),and the serum concentration of high density lipoprote in choleste rol was remarkably increased in the multinutrients-treated groups(P<0.05).Conclusion Multinutrients are effective for decreasing body weight in obese rats and improving the serum lipids in hyper lipidemia rats.