Effect of isoflavone in obesity prevention in overiectomied rats

Objective To investigate the beneficial effects of isoflavone on obesity,blood lipids and blood glucose in overiec tomied(OVX)rats.Methods Female 8 week old SD rats were randomly assigned to 6 groups.There were shamo perated control group(SHAM),ovariectomied control group(OVX),OVX with low,middle,and highiso flav ne groups(LS,IMSI,HSI),and OVX with estrogen group(EC).All anmials were a llowed freely to high fat diet and water for 4 weeks.Four weeks later,all rats were killed.Fat pad and internal organs were taken out and weighted.Blood lipids and blood glucose were examined by kits.Results Compared with OVX control,body weight,perirenal and parametrial fat weight were reduced in isoflavone groups(P<0.05).Uterus weight of high isoflavone group increased lightly(P=0.026)but other organs were not affected.Serum total cholesterol,trigly ceride levels were reduced and high density lipid cholesterol level was increased in isof lavone groups.Blood glucose was decreased significantly in middle and high isoflavone group.Conclusion Isoflavone could reduce the body weight induced by OVX,decrease abdominal fat pad deposition,and improve blood fat and blood glucose.