Silicosis fibrosis model through macrophage injury in rats

ObjectiveTo study the possibiliy and degree of macrophage injury and collapse induced by SiO₂.Methods Sterile SiO₂ solution(1ml)was injected in to abdominal cavity of Wistar rats one time.The peritoneal fluids of the rats was taken at 1st-3rd day after the exposure to observe the phayocytose and injuries of macrophages.ResultsTypical cytopathic,damage and finally breakdown resulted from the injection of SiO₂ particles were observed 4 hours after the injection.The damage rate of macrophage was up to 10%.ConclusionThe animal model of silicos is was established and could be adopted in pathogenic study of silicosis.