Association between interleukin-1F10 gene polymorphism and susceptibility of ankylosing spondylitis

Objective To investigate the associa tion between the interleuk in-1F10(IL-1F10),gene polymorphism and anky losing spondy litis(A S).Methods The polymorp hisms of IL-1F10(rs6743376 and rs6761276)gene was analysed in 178 A Spatients from a grade Ⅲ level A hospital of Anhui province and 161 health controls with ligase detection reaction based on high temperature ligase.The distribution of rs6743376 and rs6761276 genotypes and allele frequencies were detected in the two groups.Results No significant difference was found in the distribution of rs6743376 and rs6761276 genotypes and allele frequencies between AS patients and health controls.Conclusion Our study suggests that the two single nucleotide polym orphisms(rs6743376 and rs6761276 of IL-1F10)may not be a suscep tibility factor for AS in A nhui Han population.