Effect of long term excessive iodine intake on serum lipoprotein metabolism in mice

Objective To analyze the state of no socomial infection among inpatients in general intensive careunit(ICU),and to provide evidence for reducing hospital infection rate.Methods Using targetmonitoring method we comprehensively analyzed 1719 patients admitted into general ICU from Objective To study the effect of excessiveiod ine exposure on serumlipo prote in metabolism in mice and to explore its possible mechanism.Methods Sixty female Balb/c mice were randomly divided into six groups according to body weight and giveniodine at different dose of 0,300,600,1200,2 400,and 4 800 g/L,respectively,in drinking water.Serum lipoprote in and serumthy roid hormone were determined 30 days after iodine exposure.The mRNA expression of lowdensity lipoprote in receptor(LDLR)and scavenge receptor BⅠ(SR-BⅠ)were detected by real-time PCR.Results In excessive iodine groups,urinary iodine level increased dose dependently and serumthy roid hormones(thyroid stimulating hor mone,total triio dothy ronine,and total thyro xine)were not affected by iodine intake throughout the study.A dose dependent increase of serum lowdensity lipopro tein choleste rol(LDLc)level was observed in iodine treated groups.While there was no significant change in high density lipoprote in cholesterol(HDLc)level.Compared with the control group,total cholesterol and LDL cleve ls increased significantly in 2400 and 4800 g/L groups(2.40±0.37,0.39±0.11,2.58±0.42,0.41±0.11 mmol/L).A dose dependent attenuation of hepatic LDLR mRNA(r=-0.753,P<0.01)expression in parallel to the change of serum LDLC was obsorved.Conclusion The findings demonstrate a dose dependent effect of excessive iodine on LDLc and suggest that down regulation of hepatic LDLR gene may play a critical role in excessive iodine induced effect.