Antibiotic activity of compound tinidazole suppositor in vitro

Objective To study antibiotic activity of compoundtin idazole carrier supositoriesaga in stanaerobic bacteria,fungus and bacterium in vitro.Methods Compared with the results of the complex pre scription carrier suppositeries,metronidzaole,tinidazole,coltrmiax ole and chlorhex idine acetate,the minmi uminhibitary concentrations(MIC)of compoundtin idazle carrier suppolitories against anaerobic bacteria,fungus and bacterium were determined with agardilution method.Results Compound tinidazole carrier suppositories showed a strong antibiotic activity aga inst Bacteroides fragilis.Fusobacterium mucleatum,Pepto streptoco ccusanaerobius,Staphy lococcus aureus(SA),Escherichia coli,Pseudomonsa a eruginosa,gonococcus and Candia albicans,with MIC of 0.0625,0.5,0.125,16,128,64,8,16μg/mL,respeetively.For Bacteroides Fragilis,Fusobacterium mucleatum,Pepto streptococus anaero bius,the MIC of com pound tinidazole carrier suppo sitories was lower than that of the complex prescription carrier suppository.Conclusion Tinidazole carrier suppository is of broad antibiotic spectrum,high activity in vitro and lowtoxicity in gynecological inflamation treatment.