Effect of marine collagen peptide on wound healing in rat after cesarean section

Objective To observe the effect of marine collagen peptide on wound healing in rat afterce sarean section.Methods Ninety six nearterm pregnant SD rats were delivered by cesarean section.Then,the rats were randomly divided into 4 group:sthree groups of marine collagen peptide at doses of 0.13,0.38,1.15 μg/kg·bw,and the saline group through gastric tube every day.Necropsy was performed on postope rative day of 7,14 and 21.The rats in each group were used to study the uter ine bursting pressure,skin tensile strength and hydroxypro line(Hyp)content of the scar.Results The contents of Hyp in skin scartissue for 1.15 μg/kg·bw group was significantly higher than that of the control group at three time points(P<0.05).The skin tensile strength and uterine bursting pressure of 1.15 μg/kg·bw group was significantly larger than that of in control group on the 7th and 21st day(P<0.05).The skinten sile strength of 0.38 μg/kg·bw group was significantly higher than that of in control group on the 21st day(P<0.305).Conclusion The marine collagen peptide can effectively promoted the wounding healing in rats after cesarean section.