Strategy for multidrug resistant pulmonary tuberculosis case finding and treatment

ObjectiveTo analyze multidrug resistant tuberculosis(MDR-TB)case finding and treatment and to explore the case-finding and treatment strategy suitable for situation in China.MethodsData on case-finding,treatment and sputum negative conversion were collected from monthly and quarterly reports and the ratio of confirmed MDR-TB cases among different high risk groups was analyzed to evaluate high risk groups screen strategy.The use of standardized regimen among all enrolled MDR-TB cases and the sputum conversion rate at the end of six month treatment were also analyzed to evaluate the feasibility of standardized treatment regimen in China.ResultsAmong the 2 657 MDR-TB suspects with drug susceptible test(DST),880(33.1%)were confirmed MDR-TB.Totally 814 MDR-TB cases received physical examination and medical evaluation;473(58.1%)cases were enrolled in the treatment;433(91.5%)cases received standardized regimen.Among 124 MDR-TB cases that finished 6 months treatment,the sputum smear and culture negative conversion rate was 67.7% and 63.7%,respectively.ConclusionHigh risk group screening strategy is a cost-effective strategy that feasible to the current technical capacity and resources in China.Standardized regimens adapt to most of the MDR-TB cases and could achieve ideal sputum negative conversion rate.