Susceptibility of 1070 clinical isolates of Candida species to three antifungal agents

ObjectiveTo evaluate susceptibilities of Candida species to three antifungal agents.MethodsThe Candida species isolates were differentiated by CHROMagar and Vitek2 YST test kits.And the susceptibility testing was performed with broth microdilution method according to the Clinical and Laboratory Standards Institute(CLSI)M27-A2 reference method for broth antifungal susceptibility testing of yeasts.ResultsOf the 1070 isolates collected,Candida albicans was the most frequently isolated species(748,69.90%),followed by Candida glabrata and Candida tropicalis.Overall,87.8% of all Candida isolates were susceptible to fluconazole,99.5% to 5-fluorocytosine,and 40.3% to itraconazole.ConclusionAll the Candida isolates are highly sensitive to 5-fluorocytosine.However,the resistant rate of all the Candida strains to itraconazole is high.