Relationship between hyperuricemia and lipometabolism among Kazaks in Xinjiang

Objective To examine the uric acid level and analyze the correlation between hyperuricemia and lipometabolism among Kazaks in Xinjiang Uygur Autonomous Region.Methods From October 2009 to July 2010,the blood samples were collected from 128 cases of hyperuricmia and 128 controls for detections of serum uric acid(SUA)and lipidrelated indicies.Results The SUA(469.31±87.38μmol/L),blood urea nitrogen(BUN)(6.10±2.45 mmol/L),serum creatinine(SCr)(88.34±20.39μmol/L),total triglyceride(TG)(1.66±1.74 mmol/L),lowdensity lipoprotein-cholesterol(LDL-C)(2.72±1.13 mmol/L),apoloipoprotein B(Apo-B)(0.91±0.27g/L),and glucose(GLU)(6.12±2.52 mmol/L)were increased and high density lipoprotein-cholesteral(HDL-C)(1.49±0.82 mmol/L),Apo-A1/ApoB(1.36±0.42)decreased in the hyperuricemia compared to those of the controls.The concentration of uric acid of the men was higher than that of the women.There were different prevalences of lipometabolism disorder in the subjectes of different age,with a higher prevalence among the subjects at the age of 31-40 years.Correlation analyses demonstrated that the SUA was positively correlated with age,TC,TG,BUN,SCr,LDL-C,and Apo-B and inversely correlated with HDL-C and ApoA1/ApoB.Regression analyses showed that gender,HDL-C,BUN,TC,Apo-A1,and Apo-A1/Apo-B were the independent hazardous factor of hyperuricemia.Conclusion The serum lipid of the hyperuricemia is higher than that of people with nomal serum uric acid and the uric acid level of the hyperuricemia is closely correlated with lipometabolism in Kazaks.