Relationship between oxidative stress and polycystic ovary syndrome in non-obese women

ObjectiveTo investigate the relationship between oxidative stress and polycystic ovary syndrome (PCOS) in non-obese women.MethodsA case-control study involving 42 newly diagnosed non-obese PCOS patients and 46 nomal female volunteers was performed.Information on general characteristics of the subjects were collected with a questionnaire survey and serum malondialdehyde(MDA)and 8-hydroxy-desoxyguanosine(8-OHdG)levels were detected.Correlations of serum MDA and 8-OHdG levels with other variables were analyzed using Spearman correlation analysis.ResultsCompared to non-PCOS controls,the non-obese PCOS patients had significantly higher concentrations of cholesterol(CHO),total testosterone(TESTO),luteinizing hormone(LH),fasting insulin(FI),homeostasis model assessment of insulin resistance(HOMA-IR),MDA,and 8-OHdG(P<0.05 for all).Whereas follicle stimulating hormone(FSH)level was significantly lower in PCOS patients than in the controls(P<0.01).In the PCOS group,MDA and 8-OHdG were significantly associated with HOMA-IR(r=0.434,P<0.01;r=0.304,P<0.01,respectively),TESTO(r=0.339,P<0.01;r=0.378,P<0.01,respectively),and LH(r=0.217,P=0.023;r=0.326,P<0.01),indicating that serum MDA and 8-OHdG had associations with hyperinsulinemia,hyperandrogenism,and ovarian dysfunction.ConclusionSerum oxidative stress of non-obese PCOS patients is significantly higher than that of healthy control group.The mechanism of the high oxidative stress may be closely associated with hyperinsulinemia and hyperandrogenism in non-obese PCOS patients.