Association of inflammatory biomarkers with mean arterial pressure and pulse pressure among Mongolians

Objective To investigate the relationship between inflammatory biomarkers,including C-reactive protein(CRP),intracellular adhesion molecule-1(ICAM-1)and E-selectin,with mean arterial pressure(MAP)and pulse pressure(PP)among Mongolians.Methods A total of 2 589 Mongolian residents aged 20 years and older were selected with cluster sampling from two adjacent townships located in Kezuohou Banner and Naiman Banner in Inner Mongolia and were required to complete a questionnaire survey,physical examination and laboratory detection including CRP,ICAM-1,E-selectin and other biochemical indicators.The panticipants were divided according 75 th percentile of MAP and PP into an elevated MAP group(>108 mmHg),normal MAP group(≤108 mmHg),elevated PP group(>50 mmHg),and normal PP group(≤50 mmHg).Logistic regression model was used to analyze the association between the inflammatory biomarkers and MAP and PP.Results The levels of CRP and ICAM-1(12.01±10.65 mg/L and 344.28±97.45μg/L)in the group with elevated MAP were higher than those in the group with normal MAP(8.42±8.50 mg/L and 323.73±97.55 μg/L)(all P<0.001).The levels of CRP and ICAM-1(11.34±10.83 mg/L and 342.97±97.54 μg/L)were higher in the group with elevated PP than those in the group with normal PP(8.66±8.54 mg/L and 324.39±97.63 μg/L)(all P<0.001).Multivariable logistic analysis showed that,compared with the lowest quartile of CRP,the multivariable adjusted odds ratio(OR)(95%confidence interral95%CI)of elevated MAP for the highest quartile was 1.37(1.01-1.90),and compared with the lowest quartile of ICAM-1,the multivariable adjusted OR(95%CI)of elevated PP for the highest quartile was 1.38(1.03-1.85).Conclusion CRP is positively associated with MAP and ICAM-1 is positively associated with PP among Mongolians.