Relationship between expressions of serum tumor biomarkers and prognosis of breast cancer

Objective To explore associations between carcinoembryonic antigen(CEA),carbohydrate antigen 153(CA153),tissue polypeptide specific antigen(TPS) and clinical outcomes in breast cancer patients.Methods A total of 187 female breast cancer patients were selected and followed up.The data on clinical/pathological factors and clinic outcomes were collected and serum CEA,CA153,and TPS were measured among the patients.The relationships between CEA,CA153,TPS level and clinical/pathological factors and survival of the patients were analyzed.Results There were significant differences in positive rates of serum CEA and CA153 among the patients with different tumor-node-metastasis(TNM) stages and between the patients with and without lymph node metastasis(all P<0.05).There were significant differences in the positive rate of TPS among the patients with different TNM stage,lymph node metastasis status,and degree of tumor cell differentiation(all P<0.05).The survival time of the patients with either positive result of CEA/CA153/ TPS or the combination of the three indicators was significantly less than that of the patients with negative result of the indicators(all P<0.05).Cox regression analyses showed that the expression of CA153(risk ratioRR=3.462),TPS(RR=2.193) and degree of cell tumor differentiation(RR=4.215) were independent risk factors for poor prognosis of breast cancer(all P<0.05).Conclusion High serum level of CEA,CA153 and TSP may predict poor outcome for breast cancer patients.CA153,TPS and tumor cell differentiation degree may serve as prognosis factors for breast cancer.