Correlation between genetic polymorphism and susceptibility to childhood acute lymphoblastic leukemia

Objective To study the correlation between the polymorphism of glutathione S-transferase gene(GSTT1 present/null,GSTM1 present/null,and GSTP1 I105V)with the susceptibility to childhood acute lymphoblastic leukemia(ALL).Methods Totally 87 ALL patients and 120 healthy controls were enrolled.GSTT1 and GSTM1 genetic polymorphism was detected with multiple PCR and GSTP1 I 105V genetic polymorphism was detected with pyrosequencing.SPSS was employed in data analyses.Results Among the 207 samples from both the patients and the controls,the frequencies were 69.1% and 27.5% for GSTT1 wild and mutant genotype,30.9% and 72.5% for GSTM1 wild and mutant genotype,and 58%,33.8% and 8.2% for GSTP1 AA,AG and GG genotype.GSTT1 and GSTM1 null genotypes were not significantly associated with the risk of ALL(odds ratioOR=0.685,95% confidence interval95%CI:0.378-1.241 and OR=0.742,95%CI:0.396-1.390);GSTP1 GG genotype was associated with an increased ALL risk(OR=1.194,95%CI:0.645-2.150),while AG genotype was associated with a decreased ALL risk(OR=0.711,95%CI:0.237-1.820).Conclusion The genetic polymorphisms of GSTT1 present/null,GSTM1 present/null,and GSTP1 I105V are associated,but not significantly,with susceptibility to childhood acute lymphoblastic leukemia.