Association of urine isothiocyanate ester levels with lung cancer:a case-control study

ObjectiveTo explore the relationship between urinary isothiocyanates(ITCs) level and incidence of lung cancer.MethodsA case-control study was conducted among 88 lung cancer patients and 84 health physical examinees in Nanyang Municipal Central Hospital from May 2012 through November 2014,with a face-to-face survey using a self-designed questionnaire and a food frequency questionnaire.The urinary levels of isothiocvanates of the participants were measured with high performance liquid chromatography(HPLC).ResultsThe levels of cruciferous vegetables intake,ITC dietary intake,and urinary ITC were 94.7±6.4 g/day,11.7±1.0 μmol/day,and 0.93±0.2 μmol/g in the cases,respectively,lower than those(105.6±8.9 g/day,12.6±1.2 μmol/day,and 1.63±0.3 μmol/g) in the controls(all P<0.05).Multivariate logistic regression analysis showed that,after adjusting confounding factors such as gender,age,body mass index,family history of lung cancer,smoking,and tea drinking,the odd ratio of lung cancer for the partici-pants with a ITC dietary intake of ≥15.305 μmol/day was 0.70(95% confidence interval95% CI:0.51-0.96) compared to those with the intake of <9.173 μmol/day;the odd ratios of lung cancer for the participants with the urinary ITC metabolism levels of 0.825-3.342 μmol/g and ≥3.343 μmol/g were 0.68(95% CI:0.50-0.93) and 0.48(95% CI:0.32-0.72)compared to those with the level of <0.825 μmol/g,respectively(both P<0.05).ConclusionHigh intake of dietary isothiocyanates could reduce the risk of lung cancer.