Serum pertussis antibody among 0-6 years old children in Xinjiang

Objective To examine antibody level of pertussis among the healthy children in Xinjiang Uygur Autonomous Region(Xinjiang)and to provide evidences for pertussis prevention and control.Methods Totally 4354 healthy children aged 0-6 years were selected from 96 towns in 14 regions in Xinjiang.A questionnaire survey was conducted and blood samples were collected among the children.Serum immunoglobulin G(IgG)against pertussis was detected with enzyme-linked immunosorbent assay(ELISA).Results Among the children,665(15.80%,95%confidence interval95%CI:14.72%-16.88%)were pertussis IgG antibody positive;the positive rate increased with age and the children 6 years old had the highest positive rate (21.38%,95%CI:28.58%-40.24%).Among the children with 3 or 4 doses of diphtheria-tetanus-pertussis(DTP) vaccines,the IgG antibody positive rate for the children born before 2009 was significantly higher than those born after 2009.Conclusion The positive rate of IgG antibody against pertussis was very low for 0-6 years old children in Xinjiang,suggesting the children being under the high risk of pertussis.The immunogenicity of acellular DTP vaccine is lower than that of whole-cell DTP.The study on immunogenicity of pertussis vaccine component should be enhanced.