Establishment and evaluation of silencer model in Beagle dogs

Objective To establish silencer model in Beagle dogs and to evaluate physiological function of Beagle dogs with right recurrent laryngeal nerve amputation.Methods Twelve healthy Beagle dogs were randomly divided into a model and a control group;right recurrent laryngeal nerve amputation was performed in the dogs of the model group.Barking volume was measured for all the Beagle dogs at 3- and 6-month of the experiment and electrocardiogram,respiration function,and physiological and biochemical indicators of blood of the Beagle dogs were determined simultaneously.Results The barking volumes were 41.83±4.87 and 48.62±2.19 dB(A)for the control group and 33.04±2.34 and 35.20±1.98 dB(A)for the model group at 3- and 6-month,with significantly lower volumes in the Beagle dogs of model group compared to those of the control group(both P<0.05).No significant differences in electrocardiogram,respiration function,22 blood physiological indicators,and 8 blood biochemical indicators were observed between the control and model groups at 3- and 6-month of the experiment(P>0.05 for all).Conclusion Unilateral recurrent laryngeal nerve amputation can significantly reduce barking volume and has no significant impacts on electrocardiogram,respiration function,and hematologic indicators in Beagle dogs.