Associations of metabolic syndrome components and their different combinations with coronary heart disease

Objective To investigate the correlation between coronary heart disease(CHD) risks and metabolic syndrome(MS) components and different combinations of MS components, and to provide references for CHD prevention and control.Methods A questionnaire survey, physical examination, and laboratory test were conducted among 18 254 adult examinees ≥18 years selected with cluster sampling from Beijing Friendship Hospital in 2012.The prevalence of MS and the correlations between CHD and MS components and their combinations were analyzed among the participants of different groups.Results Of the participants, 29.83% were identified as MS and 1.05% as CHD.The results of univariate factor analysis showed that all the 5 MS components(obesity or overweight, hypertension, hypertriglyceridemia, low high-density lipoprotein cholesterolHDL-C, and hyperglycemia or diabetes) were risk factors of CHD(P<0.01).The results of correlation analysis showed that the participants with 4 or 5 MS components had an increased risk of CHD, with the odds ratio(OR) (95% confidence interval95% CI) of 3.16(1.94-5.14) and 4.12(1.59-10.72);the participants with higher body mass index(BMI) plus higher HDL-C had a lower risk of CHD(OR=0.06, 95%CI=0.02-0.24), while the participants with higher blood pressure(BP) plus higher fasting plasma glucose(FPG) had an increased risk of CHD(OR=4.60, 95%CI=1.44-14.69);the participants with the 3 MS components of high BP, FPG, and HDL-C had a higher risk of CHD(OR=5.08, 95%CI=1.15-22.40);the participants with the 4 MS components of high BMI, BP, FPG, and triglyceride and of high BMI, BP, FPG, and HDL-C had an increased risk of CHD with the OR(95%CI) of 4.38(1.03-18.61) and 4.33(1.20-15.66).Conclusion MS components are risk factors of CHD.CHD risk increases with the number of MS components.Different combinations of MS components present different correlations with CHD.